Blar i forfatter "Kaehler, Meike"

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    • Genome-wide expression and methylation analyses reveal aberrant cell adhesion signaling in tyrosine kinase inhibitor-resistant CML cells 

      Kaehler, Meike; Litterst, Merit; Kolarova, Julia; Bohm, Ruwen; Bruckmueller, Henrike; Ammerpohl, Ole; Cascorbi, Ingolf; Nagel, Inga (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-22)
      Although chronic myeloid leukemia (CML) can be effectively treated using BCR‑ABL1 kinase inhibitors, resistance due to kinase alterations or to BCR‑ABL1 independent mechanisms remain a therapeutic challenge. For the latter, the underlying mechanisms are widely discussed; for instance, gene expression changes, epigenetic factors and alternative signaling pathway activation. In the present study, in ...

    • Interaction of Phytocompounds of Echinacea purpurea with ABCB1 and ABCG2 Efflux Transporters 

      Awortwe, Charles; Bruckmüller, Henrike; Kaehler, Meike; Cascorbi, Ingolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-17)
      Preparations of Echinacea purpurea (E. purpurea) are widely used for the management of upper respiratory infections, influenza, and common cold, often in combination with other conventional drugs. However, the potential of phytochemical constituents of E. purpurea to cause herb−drug interactions via ABCB1 and ABCG2 efflux transporters remains elusive. The purpose of this study was to investigate ...